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I have a dual TF suggestion that will sound very cliche.
A woman takes bovine hormones to increase her bust size. It works of course but also makes her lactate. Later on, she begins to show signs of bovineism (made up word) from the hormones: including grass eating, the ever popular mooing, and the growth of horns and cow ears and tail. The comic should finish with her fully turning into a cow and possibly liking it.
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