[darththeo]

I see it being a few scene gag ... based on the fact it is shown in the preview, basically by the end of the episode it will be either resolved or forgotten. It seems odd they'll show one of there 1 time gags in an ad.

It is possible, but I doubt it. I see a few scenes for the gag, similar to the Large Marge episode of the Simpsons. Basically, Lois pestering Peter to ask or asking Jesus herself reduce her breasts.

Fetishes that have evidence in Family Guy:
1) Large Breasts/Breast Expansion - Evidence given already
2) Fat Fetish/Feedee - Sibling Rivalry
3) Pregnancy - Seriously, she has been pregnant since her introduction.