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Originally Posted by TF-Viewer
It doesn't destroy it's host. The player destroys it's host when he or she shoots it. It does mutate the host, you can clearly see the evidence of that throughout the game. If it killed it's host then the host would simply fall over and die when it's head burst open, but it doesn't die. The host continues to move about as if directed by a brain. This displays the fact that the parasite and host have merged into a single being, the host brain my no longer exist, but the body still lives. Excella may have ceased to exist as Excella the human when she transformed, but she didn't die until the player fried her with the orbital laser.
As far as Wesker goes, he was genetically engineered to be the perfect host for the Uroboros parasite. With him, he's in control of it rather than it being in control of him, that is the only difference. It's that same engineering that allowed him to gain powers from the T-Virus rather than turn into a zombie or Tyrant.
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Again, it is NOT a transformation. The Uroboros virus consumes the dead flesh to propagate itself. Excella was eaten, not transformed. If you'll look through the notes in the game, you'll see this said several times. When rejected, Oroboros eats its host and replicates itself.