I'm sure there is quite a few here that are familiar with tg manga Onimai also known as Oniichan ha Oshimai! or Onii-chan Is Done For! A anime adaptation is underway right now.
https://mangadex.org/title/ed996855-...an-is-done-for
Someone has made a 4-Koma of the manga. Basically the scientist sister creates a medicine that temporally turns her "older brother" into a shrunken down version of himself that look likes a plush doll. He later gets back at his sister with the same medicine.
https://mangadex.org/title/71008ba1-...e/petit-onimai
This process seems like a mix between shrinking and transformation but since the term Shrinking is used in the manga I put this topic here.