Both blocks in this setting, Innistrad/Dark Ascension/Avacyn Restored and Shadows Over Innistrad/Eldritch Moon, hit these themes pretty hard, though the original Innistrad block was much less tentacle-focused and more straight-forward gothic. They're all crammed full of werewolves, and there's a case of an unassuming girl-next-door type getting adopted into one of the big shot vampire families and looking a lot meaner, if that's your thing. Probably the most infamous breakout in the tournament scene was this guy:
Who managed to turn himself into this thing:
