In an episode of Pirates of Dark Water, a middle-aged maid creates a potion that makes her young again. But when it begins to wear off she fails to drink more, so she ages more and melts.
(process at 03:20)
(process at 02:50)
Also, in the Phantom comic book, there's a story called "Queen Samaris XII", about a beautiful but wicked queen who in her forty-somethings forces a witch to make her young and beautiful forever. 300 years later the spell is broken though, so she ages 300 years in a matter of seconds...
That comic has been drawn twice, first in the 1960s (kinda awfully drawn) and then in the 1990s (looks great).