In the 4th Scary Movie, the guy that plays the main character in the 3rd is shown in the beggining taking a whole bottle of aspirin, but he then notices it's actually a bottle full of viagra, and his penis grows big (around a foot or so, still covered by the pants).
He ends up falling from his apartment's window while trying to put it down, though. A pity, as he had three blondes waiting for him in his room