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[Xodiac]

I have seen it done before, for exactly that reason. It can work, but you have to make absolutely sure it's legible, raher than your usual cursive handwriting that you use to sign documents and write your notes to yourself with. Otherwise the reader is going to have a hard time figuring out what they say, which isn't exactly going to endear the comic to them. Readers shouldn't need to concentrate to understand any part of your comic.

In short: cursive to show the voice change can work, but be very careful with it.